Combined drug whose action is due to the components included in its composition. As a result, the total action of hydrocortisone and oxytetracycline drug inhibits the development of inflammatory and allergic skin reactions, complicated by a bacterial infection.
Oxytetracycline: antibiotic tetracycline. Bacteriostatic equipoise only cycle effect by inhibiting the translation process of protein synthesis in the microbial cells.
It has a wide spectrum of action, is active against gram-positive (Staphylococcus spp., Including penicillinase-producing, Streptococcus spp., Including Streptococcus pneumoniae, Clostridium spp., Bacillus anthracis, Listeria monocytogenes) and Gram (Neisseria gonorrhoeae, Bordetella pertussis, Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp.) microorganisms, and Rickettsia spp., Chlamidiaceae, Mycoplasma, Actinomyces, Mycobacterium spp., Spirochaetaceae.
Hydrocortisone – glucocorticosteroid. It has anti-inflammatory, antiallergic, antipruritic, anti-action. Stabilizes cellular and subcellular including lysosomal membrane.
Reduces the yield of proteolytic enzymes from lysosomes, inhibits the release of inflammatory mediators by eosinophils, reduces the amount of membranes and stabilizes the mast cells. Inhibits phase alteration and reduces inflammatory cell infiltrates, reduces migration of leucocytes and lymphocytes in the area of inflammation. Decreases immunoglobulins binding to receptors on the cell surface and inhibits the synthesis or release of cytokines (interleukins and interferon) of lymphocytes and macrophages. It reduces the release of arachidonic acid from the phospholipid synthesis and its metabolites (prostaglandins, leukotrienes, thromboxane). As a result of reduced congestion and exudation in the lesion. It reduces the severity of the early immunological response. Immune complexes prevents the penetration through the cell membrane and reduces the concentration of immunoglobulins and complement components. Stimulating steroid receptors, induces lipokortinov, has anti-edematous activity. Increases gluconeogenesis, reduces glucose utilization tissues and activates catabolic processes. At therapeutic doses, virtually no systemic action.
After applying ointments Oksikort the skin, the active ingredients are accumulated in the epidermis (mainly in the granular layer).
Oxytetracycline when applied topically to the skin it is practically not absorbed and has no systemic effects, minor its count after resorption biotransformation in the liver and excreted by the kidneys .
Hydrocortisone penetrates the epidermis, may be slightly absorbed from the skin into the body and have systemic effects. Absorption from the skin of hydrocortisone increases with frequent application when used on large areas of skin, when applied to the skin or folds in the skin and in the application of occlusive dressings, increasing the local temperature and humidity. Absorption of hydrocortisone from the skin of children is more pronounced than in adults, and have a higher susceptibility to systemic effects of hydrocortisone than in adults. Therefore, the preparation of children should be used in limited areas of the skin and, if possible, a short course. Hydrocortisone cumulation in the skin at the application site increases with frequent application of the preparation. Hydrocortisone metabolized directly into the epidermis, and further slight amount thereof after absorption into the bloodstream – biotransformed in the liver. In the blood 80% bound to transcortin and albumin 10%. In the form of metabolites in small amounts in unchanged form excreted in the urine and in a small amount of bile.
- bacterial skin infections caused by oxytetracycline sensitive flora (streptococcal, staphylococcal and mixed), complications include allergic reactions:
– pyoderma (strep, stafilokokovaya)
– bullous and exfoliative dermatitis newborns;
– infected diaper rash;
– boil , abrasions;
- allergodermatoses complicated by additional bacterial infection (streptococci, staphylo dermis):
– Dermatitis (incl allergic, contact, professional, solar)
– itchy dermatitis, prurigo,
– eczema, including in children
– atopic equipoise only cycle dermatitis (neurodermatitis common)
– erythema multiforme;
- burns 1st degree P;
- insect bites;
- varicose leg ulcers.Contraindications
: Hypersensitivity to the drug. Viral skin diseases, tuberculosis, syphilis, ringworm, tumors and precancerous diseases of the skin, rosacea and perioral dermatitis, skin reactions after vaccination.
Dosage and administration
Normally ointment applied thinly to the lesion 2-3 times a day; you can use a gauze occlusive dressings. The course of treatment -1-2 weeks. Children (especially under 2 years) is used on limited areas of the skin, short-course (5-7 days).
Very rarely can appear itching, rashes and skin irritation. Sometimes it is possible the accession of secondary infection caused by microorganisms resistant to oxytetracycline. With prolonged use on the face may cause steroid acne, telangiectasia, striae, skin atrophy.
Overdose is rarely observed. With prolonged use, and / or applied to large surfaces – systemic side effects of glucocorticosteroid. When you remove the drug overdose phenomena independently tested.
Interaction with other drugs
during treatment should not be vaccinated against smallpox. Should not plan to other types of immunization during treatment, due to the immunosuppressive effect of the drug. If incorrect and long-term use over large skin surfaces, especially with the use of occlusive dressings and eventual resorption of the drug in the bloodstream, hydrocortisone reduces the effectiveness of insulin, oral hypoglycemic agents, antihypertensives, anticoagulants, reduces the concentration of salicylate in the blood reduces the concentration of praziquantel serum . Increases the risk of side effects: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotics, bucarban, azathioprine (cataract); holinoblokatory, antihistamines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia);cardiac glycosides (digitalis intoxication).
The drug should not be used topically with the lead drugs and silver because of their mutual inactivation with oxytetracycline.
is recommended not to exceed a course of treatment. Do not use for a long time on large areas of skin. Avoid ointment in the eye. If necessary, application of the drug on the skin and in skin folds, treatment should be short. Use in children: . Children equipoise only cycle (especially up to 2 years), used with caution, in limited areas of the skin and, if possible, a short course Use in pregnant women and lactating women: not recommended for use in pregnant and lactating women, especially with prolonged use over large areas of the skin.