The antidote to oxaliplatin unknown. In case of overdose can be expected more pronounced equipoise for horses manifestations of dose-dependent side effects. We recommend close observation of the patient, and strict control of hematological parameters. Treatment is symptomatic.
Interaction with other drugs and other forms of interaction.
Significant changes of oxaliplatin binding to plasma proteins in vitro, while the application with erythromycin, salicylates, granisetron, paclitaxel, and valproic acid was observed.
The reaction of aluminum, the formation of sludge and reduced activity of oxaliplatin.
Pharmaceutically is not compatible with 0.9% sodium chloride solution and other salt (alkaline) solution or solutions containing the chlorides.
Introduction of oxaliplatin should be carried out under the supervision of a physician who is experienced in the use of cytotoxic drugs. Continuous monitoring of the possible toxic effects of the treatment with oxaliplatin necessary.
Regularly (once a week) and before each dose of oxaliplatin should be control of the content of the formed elements of peripheral blood and indicators of kidney and liver function.
Before the start of each cycle of therapy with oxaliplatin should be a neurological examination on identify signs of neurotoxicity.
Patients should be informed of the possibility of persistent symptoms of peripheral sensory neuropathy after the end of treatment. Localised moderate paraesthesia with functional impairment can hold up to 3 years after treatment according to the scheme of adjuvant use of the drug.
If experiencing respiratory symptoms (cough, shortness of breath, wheezing or detection of pulmonary infiltrates X-ray examination), treatment with oxaliplatin equipoise for horses should be suspended to exclude the presence of interstitial pneumonitis.
symptoms such as dehydration, paralytic ileus, bowel obstruction, hypokalemia, metabolic acidosis and renal failure may be due to severe diarrhea or vomiting, especially when using oxaliplatin in combination with fluorouracil.
Patients with allergic reactions to other platinum compounds in history should be monitored for the presence of allergic symptoms. In the case of reactions to oxaliplatin, like anaphylactic, infusion should be interrupted immediately and assign the appropriate symptomatic treatment. Further use of oxaliplatin in the case of allergic reactions is contraindicated.
If extravasation of infusion should be discontinued immediately and symptomatic treatment is to start local. The rest of the dose should be introduced into another vein.
Women and men during treatment with oxaliplatin should use reliable methods of contraception.
If you use Oxaliplatin must be observed all the usual regulations adopted for the application of cytotoxic drugs. After contact with the solution of oxaliplatin lyophilizate or on the skin or mucous membranes, they should be rinsed thoroughly with water and immediately.
Effects on ability to drive a car and operate machinery
During the period of treatment must be careful when driving and operating machinery, as equipoise for horses this drug can cause: Peripheral neuropathy, sensorineural, sensory disturbances, headache, dizziness, blurred vision, transient decrease in visual acuity, visual field loss. tritren