The frequency of adverse reactions listed below is stated in accordance with the following gradation: very common including isolated reports. From the hematopoietic system: very often – anemia, leukopenia, neutropenia, thrombocytopenia, lymphopenia; often – febrile neutropenia (including grade 3-4), against the backdrop of equipoise definition neutropenia sepsis; rarely – hemolytic anemia, immune thrombocytopenia.
On the part of the digestive system: very often – nausea, vomiting, diarrhea, stomatitis, mucositis, pain in the stomach, constipation, loss of appetite; often – indigestion, gastro-oesophageal reflux, hiccups; seldom – intestinal obstruction; rarely – colitis, including pseudomembranous colitis cases.
On the part of the central and peripheral nervous system: very often – Peripheral sensory neuropathy, sensory disturbances, headache, asthenia; often – dizziness, meningismus, depression, insomnia; rarely – increased nervousness; rarely -. dysarthria Neurotoxicity is the dose-limiting side effect. Sensory neuropathy symptoms are often triggered by the cold. The duration of these symptoms, which are typically dealt with in between courses is increased depending on the total dose of oxaliplatin. Functional disorders, which are expressed in the difficulty of making precise movements are possible consequences of damage to the sensor. The risk of functional disorders for a total dose of approximately 850 mg / m² (10 cycles) is approximately 10%, reaching 20% in the case of a total dose of 1020 mg / m² (12 cycles). In most cases, neurological symptoms improved or completely disappear after cessation of treatment. However, 3% of patients at 3 years after the end of treatment were observed or persistent localized paresthesias of moderate intensity (2.3%) or paresthesia affecting the functional activity (0.5%).
The treatment with oxaliplatin marked acute neurosensory symptoms, which usually occurs within a few hours after administration of the drug and often provoked by cold. They are characterized by transient paresthesia, dysesthesia or gipostezii, rare (1-2%) .
Acute syndrome of laryngopharyngeal dysesthesia Last manifested a subjective sense of dysphagia and dyspnea without objective evidence of respiratory distress syndrome (cyanosis or hypoxia) or laryngeal spasm or bronchospasm (no stridor or wheezing). Also equipoise definition observed phenomena such as lockjaw, dysesthesia language, dysarthria and a feeling of pressure in the chest. Usually these symptoms quickly stoped like without the use of drug therapy as well as the introduction blocker of H1-histamine receptors and bronchodilators. Increasing the infusion time during subsequent cycles of therapy with oxaliplatin to reduce the incidence of this syndrome. From the musculoskeletal system: very often – back pain; often – arthralgia, bone pain. On the part of the respiratory system: very often – cough, shortness of breath; often – rhinitis, upper respiratory tract infection; rarely – pulmonary fibrosis. Since the cardiovascular system: often – pain behind the breastbone, deep vein thrombophlebitis, pulmonary embolism. From the urinary system: often – hematuria, dysuria. Skin and skin appendages: very often – alopecia, cutaneous rash; often – skin peeling palms and soles, erythematous rash, excessive sweating, disorders of the nail. From the side of sight and hearing: often – conjunctivitis, blurred vision; rarely – transient decrease in visual acuity, visual field loss, hearing loss, cochlear neuritis Allergic reactions: rarely (when used in monotherapy) or often (in combination with fluorouracil +/- calcium folinate) can be observed bronchospasm, angioedema, lowering blood pressure and anaphylactic shock. Often there have been cases of allergic reactions such as rash (particularly urticaria), conjunctivitis, or rhinitis. Local reactions: at the extravasation of the drug – pain and inflammatory reactions at the injection site.
From the laboratory parameters: often – increasing the activity of alkaline phosphatase activity of “liver “enzymes, bilirubin, lactate dehydrogenase activity, hypokalemia, disorders of sodium and glucose in blood serum; often – increased creatinine equipoise definition concentration. Other: very often – fever, increased fatigue, increased body weight, taste disturbances. sermorelin for sale