Chronic heart failure of II degree, arterial hypertension, liver cirrhosis with portal hypertension, nephrosis, nephritis, renal form of diabetes insipidus, dis-proteinemicheskie edema, obesity trestolone for sale.
Hypersensitivity (including derivatives sulfonamides), hypokalemia, severe progressive forms of nephritis and nephrosis with a decrease in glomerular filtration equipoise cycle rate, acute kidney failure with anuria, hepatic coma, acute hepatitis, diabetes mellitus (severe), gout, disorders of water -elektrolitnogo balance, lactation, age 18 years (effectiveness and safety have been established).
Be wary . Renal and / or liver failure, allergic reactions, asthma, systemic lupus erythematosus, old age.
Dosing and Administration
Inside (usually in the morning before breakfast). Doses are selected individually depending on the severity and nature of the disease and the resulting effect. When long-term therapy is recommended to prescribe the lowest effective dose sufficient to maintain optimal effect, especially in elderly patients.
When the soft degree of hypertension – 50 mg 1 time a day, 3 times a week.
From the digestive system: nausea, vomiting, gastrospazm, constipation or diarrhea, intrahepatic cholestasis, jaundice, pancreatitis. From the nervous system: dizziness, paresthesia, asthenia (unusual tiredness or weakness), disorientation, apathy. From the senses: xanthopsia, impaired vision. From the side of hematopoiesis: thrombocytopenia, leukopenia, agranulocytosis, eosinophilia, aplastic anemia.Since the cardiovascular system: orthostatic hypotension (may increase under the influence of ethanol, anesthetics and sedative drugs, arrhythmias (due to hypokalemia). Laboratory findings: hypokalemia, hyponatremia (including those accompanied by neurological symptoms – nausea), hypomagnesemia, gipohloremichesky alkalosis, hypercalcemia, equipoise cycle hyperuricemia (gout), hyperglycemia, glycosuria, hyperlipidemia. Allergic reactions: urticaria, photosensitivity. Other: muscle spasm, reduced potency.
Symptoms: dizziness, nausea, somnolence, hypovolemia, excessive reduction of blood pressure, arrhythmia, seizures. Treatment: gastric lavage, the appointment of activated carbon inside, symptomatic therapy (including intravenous saline solution to restore the electrolyte balance of blood).
Interaction with other drugs
Increasing the concentration of lithium ions (Li + ) in blood (in the case where Li + cause polyuria may have antidiuretic action) and thus increases the risk of intoxication drugs Li + .
Increases the curariform muscle relaxants and hypotensive agents (including guanethidine, methyldopa, beta-blockers, vasodilators, blockers “slow” calcium channels, monoamine oxidase inhibitors).
In patients receiving cardiac glycosides may aggravate violations arising from digitalis intoxication heart rhythm.
hypokalemic effect of the drug is enhanced by concomitant administration of gluco-corticosteroid agents, amphotericin, and carbenoxolone.
Nonsteroidal anti-inflammatory drugs weaken the diuretic and antihypertensive effect of the drug.
It may require adjustment (increase or decrease) in insulin dose and increase the dose equipoise cycle of oral hypoglycemic agents.
In the period of treatment should periodically determine electrolytes of blood, especially in patients receiving digitalis preparations.
Not recommended for patients is very strict salt-free diet.
If signs of hypokalemia (myasthenia gravis, heart rhythm disorders), or if patients with more opportunities potassium loss (vomiting, diarrhea, malnutrition, liver cirrhosis, hyperaldosteronism, therapy adrenocorticotropic hormone, corticosteroids) shows replacement therapy potassium therapy.
patients with hyperlipidemia should continuously monitor the blood serum lipids (in the case of an increase in their concentration should discontinue therapy).
in patients receiving thiazide diuretics It noted exacerbation of systemic lupus erythematosus. Although such events while taking chlorthalidone have been identified, caution should be exercised when administered to patients with systemic lupus erythematosus. steroiden kaufen
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